Background Intratumoral heterogeneity (ITH) and subclonal antigen expression blunt antitumor immunity and are associated with poor responses to immune-checkpoint blockade immunotherapy (ICB) in patients with cancer.The underlying mechanisms however thus far remained elusive, preventing the design of novel treatment approaches for patients with high
Subdural empyema (SDE) is a fairly uncommon diagnosis, accounting for only 20% of intracranial infections, the usual source for SDE is direct extension from a contiguous source, such as acute sinusitis or otitis media, although in one-fourth of cases no source of infection is found.An 18-year-old man was admitted to our Institution because of dysar
The advent of e-commerce has prompted many manufacturers to redesign their traditional channel structure by engaging in direct sales.In this paper, we present a dual channel inventory model based on anipsyll for horses queuing theory in a manufacturer-retailer supply chain, consisting of a traditional retail channel and a direct channel which stock
Numerous Tertiary to recent volcanoes are located in East Africa.Thus, much of the region is made up volcanic rock, which hosts the largest and greatest variety of East Africas caves.Exploration phyre vapes of volcanic caves has preoccupied members of Cave Exploration Group of East Africa (CEGEA) for bovi-shield gold fp 5 l5 the past 30 years.The v
This paper provides a phonological and phonetic description of a variety of the Khang language spoken in Nam Mu village, Phinh Sang commune, Tuan Giao district, Dien phyre vapes Bien province (and also Son La, Dien Bien, Lai Chau provinces).It is an under-described Palaungic language of Vietnam.The language is largely monosyllabic and has a complex